Week 6 is here, and the fantasy landscape is full of both golden opportunities and potential disasters. From quarterbacks primed to break out under the lights to tight ends facing tough coverage, we break down who to start, sit, and target for maximum fantasy impact. Let’s dive into the best and worst matchups heading into Week 6.
Quarterback
Best: QB Jayden Daniels, Washington Commanders
Jayden Daniels returns to primetime with a perfect opportunity to deliver his first breakout fantasy performance of the year. Washington‘s dual-threat quarterback faces a Bears team on Monday Night Football that’s allowing 389 yards per game and the fifth-most fantasy points to opposing quarterbacks.
Daniels has yet to post QB1 numbers this season, but with Terry McLaurin expected back and Deebo Samuel quickly emerging as a go-to target, his supporting cast is trending up. His rushing upside has remained untapped due to a lingering knee injury, but that could change against a defense he torched for 52 rushing yards and 300+ passing yards last season. He’s still searching for his first rushing touchdown of the year — and if there ever were a time for that to change, it’s this week.
Chicago may be rested coming off a bye, but Monday night should still belong to Daniels. Under the lights at home, he’s set up to finally deliver his first elite fantasy outing of the season.
Worst: QB Justin Fields, New York Jets
Jets QB Justin Fields faces a challenging Week 6 matchup against the Denver Broncos, who have allowed the second-fewest fantasy points per game to the position. Denver’s defense has limited quarterbacks to an average of just 200.2 passing yards per game, with only four touchdowns allowed through the air over five games.
While Fields’ rushing ability has been a significant part of his fantasy value, this week’s matchup pokes holes there, too. Denver’s defense has been highly effective at containing mobile quarterbacks, allowing a league-low 15 rushing yards per game to the position, and it just contained Jalen Hurts and Saquon Barkley to 45 total rushing yards in Week 5.
The Broncos’ pass rush, combined with shutdown cornerback Patrick Surtain II, could prove too disruptive for a Jets’ offensive line that has struggled to provide consistent protection (Fields was just sacked five times against a weak Dallas defense last week). Managers should view Fields as a high-risk option, with upside capped this week against Denver’s stout defense.
Running Back
Best: RB Ashton Jeanty, Las Vegas Raiders
Ashton Jeanty’s early-season struggles feel like a distant memory after his Week 4 explosion, and he’s got another prime opportunity to build momentum in Week 6. The rookie running back faces a Titans defense that allows the third-most fantasy points per game to opposing backs, and is still searching for answers despite coming off their first win.
Jeanty has been heavily involved in the passing game over the last two weeks, racking up seven catches on nine targets for 59 yards and two receiving scores. Even in last week’s blowout loss to the Colts, he set career highs in targets, receptions, and receiving yards, showing his growing role in all phases. The Raiders’ offense remains inconsistent, but Jeanty’s explosiveness and dual-threat usage should be on full display upside against a soft Tennessee run defense. This is the matchup where Jeanty reminds fantasy managers why he was drafted as an RB1.
Worst: RB Derrick Henry, Baltimore Ravens
Derrick Henry‘s dominant Week 1 performance against Buffalo feels like ages ago. Since that explosion, the veteran back hasn’t cracked 50 rushing yards in any of his last four games, grinding out just 2.2 yards per carry in Week 5. He’s found the end zone twice over that span to salvage his fantasy totals, but the efficiency has completely disappeared.
Week 6 doesn’t offer much reprieve. The Rams rank among the league’s stingiest against running backs, allowing the second-fewest fantasy points to the position. Game script also looms as a concern: with Lamar Jackson likely sidelined, Baltimore could again struggle offensively. Henry thrives when the Ravens control the game script and can feed him carries to wear down defenses. With Cooper Rush under center and a shaky defense that can’t stop anyone, that scenario seems unlikely against a loaded Rams offense.
Last week’s one-yard touchdown prevented a complete fantasy disaster, but Henry’s rushing upside is capped in this week’s matchup. Managers should temper expectations until Baltimore’s offense stabilizes.
Wide Receiver
Best: WR Tetairoa McMillan, Carolina Panthers
Tetairoa McMillan has emerged as the clear WR1 for the Panthers, steadily commanding targets and consistently producing even without a touchdown through five games. The rookie has recorded 8+ targets in four straight contests and has a season total of 24 receptions for 351 yards on 43 targets. McMillan has also flashed big-play ability, recording multiple 20-plus-yard catches in three of his five games as he continues to grow his chemistry with Bryce Young.
Week 6 presents a favorable spot for McMillan against a Cowboys secondary that has surrendered the most fantasy points per game (38.6) to opposing wide receivers. Outside of Week 1, Dallas has allowed multiple 50+ yard receiving games and 10 touchdowns to opposing WRs. With volume locked in and a soft matchup looming, McMillan has a strong chance to hit the end zone for the first time, projecting as a WR2/3 with high volume upside.
Worst: WR Jameson Williams, Detroit Lions
Jameson Williams has yet to deliver consistent fantasy value this season, with just one meaningful outing through five games. The Lions’ speedster is averaging only 4.2 targets and 44.6 yards per game, despite playing at least 82% of Detroit’s offensive snaps. While he remains a big-play threat — leading the NFL with 20.3 yards per reception — his low target volume and limited involvement have made him little more than a boom-or-bust flex option.
Week 6 offers no relief. The Chiefs have been stout against opposing wide receivers, surrendering the eighth-fewest fantasy points per game to the position, and rank in the top 10 overall pass defenses. Even if this game becomes a shootout and forces Detroit’s offense to spread the field, Williams has yet to post more than two catches in a game since Week 1.
Fantasy managers should approach him cautiously, as his ceiling remains heavily dependent on explosive plays that are unlikely to come against a stingy Chiefs defense looking to rebound at Arrowhead in a primetime Monday night matchup.
Tight End
Best: TE Tucker Kraft, Green Bay Packers
Packers TE Tucker Kraft has quietly emerged as one of the top fantasy tight ends this season, currently sitting as TE6 with 12.6 PPG. The third-year pass-catcher leads all tight ends with 9.9 yards after the catch per reception and has seen 60% of his snaps lined up in-line, giving him consistent involvement in the offense.
Week 6 presents a prime opportunity for Kraft against a Bengals defense that has been thoroughly exploited through the middle. Bengals are allowing a league-high 15.2 fantasy points per game to tight ends, and are absolutely reeling defensively. They’re allowing the 3rd most overall points per game (31.2) and just let Sam LaPorta go off for 5 catches, 92 yards, and a score.
With Jordan Love targeting him frequently, Kraft is poised for another productive outing and could easily continue his streak of four-plus targets per game.
Worst: TE Kyle Pitts, Atlanta Falcons
Kyle Pitts has had a solid start to the 2025 season, but Week 6 presents a tough challenge against a Bills defense that has dominated against tight ends. Through five games, Buffalo has allowed just 11 catches, 113 yards, and a single touchdown to the position. In addition, they’ve allowed the second-fewest fantasy points to tight ends, and held early standouts Juwan Johnson and Hunter Henry to a combined 5 catches for 74 yards.
Despite their early offensive success, Atlanta ranks in the bottom 10 in completions per game and second-to-last in passing touchdowns per game. To put things into perspective, the Bills’ defense ranks second in the league for fewest passing yards (154) and completions (17.2) allowed per game, further limiting Pitts’ ceiling. While the 25-year-old veteran has surprised so far this year, don’t expect him to continue to do so in Week 6.
