Fantasy football managers know that every lineup decision can make or break a week, and choosing the right players to start or sit is where championships are won. With the 2025 NFL season underway, matchups, stats, and trends are more important than ever. From favorable matchups and scoring trends to players you should avoid in tough spots, my weekly positional start and sit guide is built to give you an edge.
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Wide Receivers to Start
Stefon Diggs NE
Stefon Diggs continues to prove why he needs to be in starting lineups heading into Week 6. Over the last two games, he’s been one of the league’s most dominant receivers, commanding a massive 42% target share and 54% air yards share, while ranking 3rd in total targets. His chemistry with Drake Maye has been electric, producing 16 catches for 247 yards and at least 16.1 PPR points in each of his past two games. What’s especially impressive is how efficient he’s been, ranking fourth in separation and 15th in route win rate among all wide receivers since Week 4. Those numbers aren’t just volume-driven; they show a receiver winning consistently at every level of the field.
This week’s matchup with New Orleans shouldn’t scare fantasy managers off. While the Saints rank seventh in fewest fantasy points allowed to wideouts, they’ve still given up 17.9+ PPR points to four receivers already this season. New Orleans also struggles against perimeter threats, surrendering the second-most PPR points per target and tenth-most receiving yards per game to receivers lining up outside. With his recent spike in downfield usage (10.4 air yards per target) and strong red zone involvement, Diggs is set up for another big performance. Keep him locked into your starting lineup with confidence.
Zay Flowers BAL
Zay Flowers continues to carve out a dependable role for fantasy managers, ranking as the WR19 in fantasy points per game and maintaining a strong 27.1% target share on the season. Even without Lamar Jackson last week, Flowers posted five receptions for 72 yards and a 25% target share, proving he can sustain fantasy relevance regardless of quarterback play. Flowers’ role within the offense is stronger than it has been in years past, with his 30% 1st read share and ranks top 10 in the NFL in target share. The TDs have not come just yet, but the usage is encouraging and has produced more consistency to start the season.
This week’s matchup with the Rams sets up favorably for Flowers. Los Angeles has allowed the ninth-most receiving yards per game and the 12th-most fantasy points per game to perimeter wide receivers, which aligns perfectly with Flowers’ usage. Even with Cooper Rush under center again, the Ravens’ offensive design ensures Flowers gets consistent first-read looks and intermediate opportunities. Expect the Rams to stack the box to stop Derrick Henry, allowing better matchups for Flowers on the outside. Expect WR2/3 production with legitimate upside if he breaks a deep ball or finds the end zone. He’s a strong start in PPR formats this week.
Ladd McConkey LAC
Ladd McConkey finally had some positives work his way and now has Omarion Hampton sidelined and the Chargers leaning even more on their passing attack. He’s coming off his best performance of the year, recording 14.9 PPR points and scoring his first touchdown, marking his second top-24 finish of the season. Over his last three games, McConkey has seen a steady 18.7% target share with a 22.5% first-read share, along with three red zone targets. While those numbers aren’t particularly flashy for a player drafted as high as he was two months ago, the matchup this week is enticing.
This week’s matchup against Miami offers another opportunity for McConkey to thrive. The Dolphins have allowed the fifth-most PPR points per target and the second-highest passer rating when targeting slot receivers, an area where McConkey lines up over 61% of the time. Expect Herbert to lean on McConkey even more this week based on the matchup. While all of the Chargers’ receivers have good matchups in this one, McConkey is in line for the biggest game of the bunch. McConkey is a low-end WR2 with WR1 upside this week against the Dolphins.
Wide Receivers to Sit
Jameson Williams DET
Jameson Williams remains one of the most frustrating fantasy wideouts in the league, and he’s an easy sit for Week 6. Despite elite athleticism and deep-threat ability, his production has been inconsistent and volatile, ranking as the WR63 in fantasy points per game. Williams has just a 15% target share, with 40% of his targets being deep shots, highlighting his boom-or-bust usage. His 19.4 air yards per target lead nearly the entire NFL, yet that hasn’t translated into steady output, as evidenced by his two-point fantasy performance last week. Detroit’s new offensive approach has emphasized short-to-intermediate passing, leaving Williams isolated as a low-volume field stretcher.
The matchup against Kansas City only makes matters worse. The Chiefs have been one of the best defenses against perimeter deep threats, allowing the sixth-fewest deep passing yards per game, the seventh-lowest deep completion rate, and the lowest deep passer rating in the NFL. Additionally, they utilize a two-high coverage shell over 62% of the time, and Williams has been nearly invisible against that look, earning just an 8.8% target share and 1.32 yards per route run. Unless you’re desperate for a Hail Mary play, Williams belongs on your bench. This is not the week to take the risk in Williams.
Brian Thomas Jr. JAC
Brian Thomas Jr. has flashed moments of promise this season, but he still profiles as a sit for Week 6. Despite back-to-back WR3 finishes (WR31, WR30), he’s averaged only 48.8 receiving yards per game with 1.53 yards per route run, and he has yet to find the end zone. Thomas holds a respectable 21.9% target share and 25% first-read share, but those opportunities haven’t translated into consistent fantasy value. His Week 5 outing (4 catches, 80 yards, 12 PPR points) was his best yet, but that stat line highlights his ceiling more than his floor. Without a strong red zone connection and with inconsistent quarterback play, Thomas remains a risky flex option.
This week’s matchup against Seattle is less than ideal. The Seahawks rank 12th in fewest fantasy points allowed to opposing receivers and are especially stingy against perimeter options, allowing the sixth-fewest PPR points per target. Thomas’s role as an outside receiver limits his scoring chances against this disciplined secondary. Unless you’re in a deep league that starts three wideouts, he’s better left on your bench. Consider this another week to sit Thomas and wait for a more favorable matchup before trusting him in fantasy football lineups.
Tee Higgins CIN
Tee Higgins continues to disappoint fantasy managers, entering Week 6 as the WR59 in fantasy points per game. He’s seen some opportunities, four red zone targets in his last four games, but his production has been pedestrian at best. Higgins is averaging just 31.6 receiving yards per game and a 16.9% target share this year. His 48% catch rate ranks among the five worst in the league (minimum 25 targets), and Cincinnati’s passing offense hasn’t been efficient enough to support multiple fantasy-relevant wideouts. While Ja’Marr Chase remains a weekly start, Higgins has become a touchdown-dependent flex play at best.
Week 6 doesn’t offer much hope for a rebound. The Packers have allowed the tenth-fewest PPR points per target to perimeter receivers, and their defensive scheme is built to eliminate big plays downfield, the area where Higgins typically thrives. Until the Bengals’ passing rhythm improves, or perhaps until Joe Flacco fully settles in, Higgins is too risky to trust. His floor is dangerously low, and his ceiling has been capped all season. Keep him on your bench this week and look elsewhere for more stable fantasy production.
