Indianapolis Colts @ Los Angeles Chargers
Stat: Jonathan Taylor leads the NFL with four rushing touchdowns outside the tackles this season.
Jonathan Taylor’s explosiveness has been unmatched this season, and that could spell trouble for a Chargers defense that’s already surrendered the most rushing touchdowns outside the tackles (five). With Taylor also leading the league in rushing yards (603), touchdowns (7), and explosive runs (15 of 10+ yards), Indianapolis’ best path to an on-the-road win looks to be in getting Taylor the ball.
On the other side of this NFL matchup, look for the Chargers to exploit the Colts’ weakness for slot receivers with players like Ladd McConkey. Indianapolis has allowed the fourth-most fantasy points per game to wide receivers this season.
A Few More Things:
- Chargers’ defense ranks worst in rushing TDs allowed outside the tackles (5).
- Colts’ offense faces a below-average Chargers pass rush (28th in pass-block win rate).
- Taylor leads the league in yards after contact (324).
New Orleans Saints @ Chicago Bears
Stat: The Saints have allowed multiple passing touchdowns in eight straight games.
The Saints’ secondary, quietly becoming one of the most generous units in football, could be a green light for Caleb Williams, who’s coming off solid production through five games with nine passing TDs and a 61.6% completion rate.
Chicago’s offensive line, ranking eighth in pass block win rate (66.2%), should give Williams time to exploit mismatches with DJ Moore and rookie Rome Odunze. New Orleans’ inability to finish drives — ranked 29th in red zone touchdown efficiency (42.1%) — will need to improve to compete with the Bears’ offense.
With the Saints also surrendering the fourth-most rushing yards to opposing QBs, this could be a killer spot for daily fantasy players looking to stack the Bears.
A Few More Things:
- Williams averages 235.8 passing yards and 1.8 TDs per game this season.
- DFS angle: Bears’ passing stack (Williams-Moore/Odunze) in a soft coverage matchup has strong ceiling potential but could be chalk and heavily owned.
Washington Commanders @ Dallas Cowboys
Stat: Dak Prescott has an 11-2 record against Washington, winning seven of his past eight starts against the Commanders.
Prescott’s dominance over Washington has been a constant throughout his career — especially at home, where he’s 6-0 with 17 touchdowns and no interceptions at AT&T Stadium. Dallas enters this matchup ranked third in scoring and first in total yards per game, testing a Washington defense that sits 26th in yards allowed.
Prescott’s recent stretch has been pretty impressive: 11 touchdowns, no turnovers, and 817 yards over the past three games — yet Dallas is only 1-1-1 in that span.
If Washington’s defense doesn’t generate pressure or disguise coverage, Prescott’s chemistry with players like Jake Ferguson and George Pickens could quickly dictate tempo in this NFL matchup.
A Few More Things:
- The Cowboys have scored 40, 37, and 27 points in their past three games.
- Jake Ferguson’s 44 receptions are tied for the third most through six games in NFL history.
- Commanders RB Jacory Croskey-Merritt led the backfield in Week 6 usage and faces a Dallas defense allowing the third-most fantasy points to RBs.
- Commanders must shorten third downs (averaging 7 yards on 55% of attempts).
READ MORE: Week 7 Fantasy Football Start and Sit Wide Receivers
Atlanta Falcons @ San Francisco 49ers
Stat: Atlanta’s defense is allowing an NFL-low 253.4 yards per game.
What makes this NFL matchup intriguing is how the Falcons’ defensive discipline contrasts with San Francisco’s usual efficiency outside zone. The 49ers have struggled to defend outside zone running style, giving up 6.2 yards per carry — a vulnerability that could be exploited by Atlanta’s run-heavy approach.
With Fred Warner and Nick Bosa missing, you have to wonder how this plays out, considering they may need offense to compensate for a strict Falcons’ defense. Not to mention, the 49ers’ rushing attack is averaging just 3.1 yards per carry, the lowest mark in the league, even with McCaffrey active.
Key Points:
- Bijan Robinson has averaged 21.4 touches and 24.8 fantasy points per game.
- Drake London joins Ja’Marr Chase and Puka Nacua as the only players this season with 10 receptions and 150+ yards in a single game.
- The Falcons lead the NFL in rushing attempts per game.
- The Falcons are running outside zone 64% of the time compared to San Francisco’s 57%.
