Fantasy football managers know that every lineup decision can make or break a week, and choosing the right players to start or sit is where championships are won. With the 2025 NFL season underway, matchups, stats, and trends are more important than ever. From favorable matchups and scoring trends to players you should avoid in tough spots, my weekly positional start and sit guide is built to give you an edge.
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Quarterbacks to Start
Jordan Love GB
Jordan Love should absolutely be on your fantasy football start radar in Week 6. The Packers’ signal-caller enters this matchup fresh off a bye and coming off one of his best outings of the year, torching Dallas for 337 yards, three touchdowns, and 26.28 fantasy points. He’s been a quietly consistent performer, ranking as the QB15 in fantasy points per game and posting a QB6 finish earlier this season. Love has been among the most efficient passers in the NFL, ranking top-10 in yards per attempt, completion percentage over expected (CPOE), and hero throw rate. When kept clean, he’s been elite, leading all quarterbacks in expected points added (EPA) when not pressured.
This week, Love faces a Bengals defense that looks like a dream matchup for fantasy purposes. Cincinnati has allowed 19+ fantasy points to three of the last four quarterbacks it’s faced while surrendering the second-most passing touchdowns and ranking bottom-10 in yards per attempt allowed. They also generate pressure at the fourth-lowest rate, which sets up perfectly for Love’s strengths. If the Packers’ offensive line gives him time, he has a real shot at another top-10 fantasy finish. Lock Love into your lineup with confidence this week; he’s a strong start in all formats.
Matthew Stafford LAR
Matthew Stafford is red-hot entering Week 6 and should be locked into your fantasy football lineups. After an inconsistent start, Stafford has exploded with back-to-back 375+ yard, three-touchdown performances, averaging over 25 fantasy points per game during that stretch. His command of the Rams’ offense has been masterful, ranking second in both passing yards per game and touchdown passes among all quarterbacks. Stafford’s ability to make difficult throws, shown by his league-best hero throw rate, has helped him sustain elite fantasy production while also having Puka Nacua and Davante Adams at his disposal. When he’s in rhythm, few QBs can match his efficiency and ceiling.
This week’s matchup against Baltimore gives Stafford another chance to shine. The Ravens’ secondary is banged up and struggling mightily, allowing the most passing touchdowns, the third-most passing yards per game, and the sixth-highest success rate per dropback. They’ve also surrendered the second-most fantasy points per game to opposing quarterbacks while failing to generate consistent pressure. That combination plays right into Stafford’s hands, as he thrives when given time to dissect defenses. Keep riding the hot hand, Stafford is a clear fantasy start with legitimate QB1 upside this week.
Daniel Jones IND
Daniel “Indiana” Jones finds himself in an intriguing spot for Week 6. Coming off his best game since Week 2, Jones has always been notably more effective against bad pass rushes, and this week, he draws an Arizona defense that ranks below average in pressure rate. Despite being held under 17 fantasy points in three straight games, Jones remains efficient as a passer, ranking top-10 in yards per attempt, passer rating, and catchable target rate among 40 qualified QBs. The results haven’t fully shown up in fantasy yet, but the underlying metrics suggest better days ahead. His dual-threat ability still gives him a safe floor, even if the rushing touchdowns have temporarily disappeared.
The Cardinals’ defense has been inconsistent, which gives Jones some upside as a sneaky fantasy start in deeper leagues. Arizona has allowed the fourth-most passing yards to quarterbacks, but has held strong in passer rating and yards per attempt, showing they can be beaten through volume more than efficiency. If Jones can find the end zone through the air and add a bit on the ground, he could easily post QB1 numbers. This isn’t a must-start spot, but it’s a positive one, and a bounce-back fantasy performance feels well within reach. Jones deserves streaming consideration for Week 6.
Quarterbacks to Sit
Jared Goff DET
Despite an impressive Week 5 outing, Jared Goff should be on your sit list for Week 6. His 20.1 fantasy points against Cincinnati came against one of the worst defenses in football, and the matchup gets far tougher this week against the Kansas City Chiefs. Goff has historically struggled outdoors, combining for just 27.5 fantasy points in two other outdoor games this season (at Green Bay and Baltimore). The Chiefs have allowed only one quarterback, Justin Herbert in Week 1, to throw for multiple touchdowns, and no one has surpassed 225 passing yards against them since. That kind of defensive consistency spells trouble for a stationary quarterback like Goff.
Kansas City’s defense is especially stingy against pocket passers, allowing the ninth-lowest passer rating and the 14th-fewest yards per attempt on the season. Where they have struggled is against rushing quarterbacks. With Goff averaging just 6 rushing yards per game, his fantasy ceiling is heavily capped. Unless you’re in a Superflex or two-QB league, it’s best to fade him this week. Expect modest production and a likely finish outside the top-15 fantasy quarterbacks in Week 6.
Trevor Lawrence JAC
Trevor Lawrence delivered one of his best fantasy football performances of the season in Week 5, finishing as the QB5 behind two rushing touchdowns and a season-high 54 yards on the ground. However, fantasy managers should be cautious chasing that performance into Week 6. Before that breakout, Lawrence had just 32 rushing yards total through four games, suggesting that kind of ground production isn’t sustainable. Through the air, he’s been merely average, ranking 29th in yards per attempt and 24th in highly accurate throw rate. While he’s shown flashes of improvement, his overall fantasy consistency just hasn’t been there.
This week, Lawrence faces a tricky Seahawks defense that’s quietly improving. Seattle ranks middle-of-the-pack in most categories but generates pressure at an above-average rate, which could disrupt Jacksonville’s passing rhythm. They’ve given up the seventh-most passing yards but haven’t been burned for many touchdowns, keeping most opposing quarterbacks in check. Unless Lawrence can replicate his rushing output, which seems unlikely, his fantasy ceiling is limited. He’s a borderline QB2 and a recommended sit in standard one-quarterback leagues for Week 6.
Justin Fields NYJ
Justin Fields has been one of fantasy football’s most exciting quarterbacks this season, topping 25 fantasy points in three of his four starts. However, Week 6 presents a brutal matchup that makes him a risky start. The Broncos’ defense, despite its inconsistencies, ranks second in fewest fantasy points allowed to opposing quarterbacks. They’ve completely shut down rushing production from the position, holding every quarterback under six rushing yards. That’s bad news for Fields, whose fantasy value heavily depends on his legs.
Compounding the problem is the Jets’ offensive line, which has allowed pressure at the highest rate in the NFL, 10 percentage points higher than any other team. Denver also boasts an elite secondary led by Patrick Surtain II, who should make life difficult for Garrett Wilson and limit Fields’ passing options. Even though Fields has been electric in recent weeks, this is a matchup to avoid if you have another viable quarterback. He’s a borderline starter at best and a clear fantasy sit in standard one-QB leagues for Week 6
