The 0-3 New Orleans Saints head to Orchard Park, NY, to take on the 3-0 Buffalo Bills. The Saints are looking for a spark after a rough start to their 2025 season, while the Bills are looking to step on the gas and maintain the gap they have over the Ravens and Chiefs.
Stats to Know
Starting with the offenses, the Buffalo Bills, led by reigning MVP Josh Allen, lead the league in total yards per game (420.0)and are 4th in points per game (34.0), while the Saints are 19th in yards per game (302.0) and 29th in points per game (15.7)—a 108.0-yard and 18.3-point advantage in Buffalo’s favor.
Now, how do their defenses fare in this matchup? Buffalo’s defense ranks 9th in yards allowed per game (287.3), while they are shockingly low on the points allowed per game category, ranking 20th with 23.7 points allowed per game. New Orleans, on the other hand, is 15th in yards allowed (313.3) and 25th in points allowed per game (30.0). Buffalo’s defense, on average, allows 26 fewer yards and allows 6.3 fewer points per game.
So if we take these numbers and average them out, the Bills’ offense should have around 366 total yards and about 32 points, while the Saints’ offense should have around 295 yards and about 19 points on Sunday. This gives the Bills a 13-point advantage overall with the line from Vegas being -14.5, and the Saints being 0-3 covering the spread, Bills 2-1 covering. Betting Buffalo -14.5 might not be a bad idea this weekend.
Hot & Cold
As always, let’s take a look at some players on both teams that are hot and some that are cold heading into this cross-conference matchup.
- James Cook isn’t just hot, he’s on an absolute heater right now. Coming off a third consecutive game in which he has put up at least 100 yards and a TD, he’s also currently RB3 in fantasy PPR formats, scoring at least 20.0 points every week so far. Look for Cook to continue cooking this Sunday vs a weak Saints team.
- Ray Davis, who is averaging 2.6 yards per carry this season, didn’t get a carry in week 3, which is only the third time in his career that’s happened (weeks 5 and 14 last season). This comes as a bit of a shock after getting 9 carries in week 2. Davis just hasn’t had the impact that Sean McDermott had hoped for in his 2nd year RB, and with Ty Johnson showing some reliability in his limited 3rd down role, could we see Davis fall down the depth chart already?
- Juwan Johnson has been exemplary this season, being a great check-down option for 2nd year QB Spencer Rattler. Like James Cook, Johnson is 3rd in his position group in fantasy for PPR leagues and is doing what most tight ends aren’t, and that’s being consistent. Johnson is averaging over 9 yards a catch and has 49 or more yards in each game this season.
- Chris Olave is in a weird position with his QB being so bad (0-9 in 9 starts). Olave only has 165 yards while being targeted 37 times. For perspective, that’s about half the yards he had per target last season. Olave isn’t going to be able to showcase his skills with Spencer Rattler at QB.
Game Predictions
I’m taking the Buffalo Bills here in a 37-20 victory over the New Orleans Saints. Buffalo covers the spread, James Cook gets a TD, and Alvin Kamara gets 100 total yards for the second time this season.
Check out all of my previous articles alongside all regular season articles available here: 2025 Season Series, and make sure to use code DL10 for 10% off all memberships! Also, tune in on YouTube to view our most recent video, where we discuss whether or not the Indianapolis Colts are legitimate threats this season to make some noise in the playoffs.
