Houston Texans (0-2) @ Jacksonville Jaguars (1-1)
Stat: Jacksonville leads the league with 169.5 rushing yards per game behind an offensive line that ranks fifth with a 75.7% run block win rate.
The Jaguars enter Week 3 with the NFL’s best ground game, averaging 169.5 rushing yards per game behind an offensive line that ranks fifth with a 75.7% run block win rate. Travis Etienne Jr. is a clear high-end RB1 option, while Bhaysul Tuten is carving out a bigger role after posting 74 yards and a touchdown with 18 snaps in Week 2.
Houston defense that sits 24th in run stop win rate (27.5%) and has allowed explosive gains on the ground, Jacksonville’s backfield carries significant fantasy upside.
C.J. Stroud’s protection will be the determining factor this week. The Texans are just 3-8 when he has been sacked three or more times, and defensive lineman Travon Walker is a threat to add pressure against Houston’s shaky offensive line. Jacksonville cornerback Tyson Campbell will also be one to watch on the Jaguars defense after giving up two touchdowns last week.
Houston is leading the league in pass rush win rate (56.8%) but struggling with the run block win (27.5%) , the Jaguars’ ability to control the game on the ground may decide the outcome.
Unders have hit in 13 of Houston’s last 19 games, the highest rate in the league, suggesting this divisional clash could lean toward a lower-scoring result despite Jacksonville ranking fourth in total offense at 389 yards per game.
LA Rams (2-0) @ Philadelphia Eagles (2-0)
Stat: Through two games, the Rams’ defense has allowed only one total touchdown.
Eagles have been dominant overall, winning 18 of their last 19 games and leaning on a rushing attack that outgained Los Angeles 599-203 in 2024. Saquon Barkley alone rushed for 460 yards in the regular season and playoffs combined. Despite this, major factor in winning relies on the Rams defense stepping up on Sunday.
Matthew Stafford has connected well with Davante Adams and Puka Nacua, completing 15 passes of 15+ yards this season thus far. Adams remains a firm WR1 thanks to elite usage metrics, while Nacua is a steady WR2 with consistent volume.
Kyren Williams holds solid value but faces capped upside with Blake Corum earning more snaps and goal-line opportunities. Philadelphia’s sixth-ranked run stop win rate also makes the Rams’ backfield a tougher sell.
Dallas Cowboys(1-1) @ Chicago Bears (0-2)
Stat: Dak Prescott is completing 75% of his passes on third down and 64% of his passes when pressured this season through 2 games.Â
Prescott is chasing his 18th career game with 350 yards and two touchdowns, which would move him past Tom Brady for the second-most since 2016. The Cowboys are facing a banged-up Chicago secondary missing Jaylon Johnson and possibly Kyler Gordon, Prescott has favorable opportunities to extend that streak.
Keep a close eye on George Pickens, who already has five end-zone targets from Prescott and has favorable boundary matchup against the Bears. Jake Ferguson is also a reliable option for fantasy after posting nine catches for 78 yards in Week 2, pushing his season average to 50.5 yards per game. With Prescott’s efficiency carrying over under pressure, both pass catchers carry strong upside in this spot.
Arizona Cardinals (2-0) @ San Francisco 49ers (2-0)
Stat: Kyler Murray has averaged 52.8 rushing yards per game against the Niners in his career.
Kyler Murray’s dual-threat element has consistently caused problems for the 49ers’ defense and remains Arizona’s best path to an upset.
The Cardinals have started 2-0 despite being outgained by at least 25 yards in both contests, a trend that only one other team (2020 Seahawks) this century has turned into a 3-0 start. Rookie receiver Marvin Harrison Jr. has been efficient but not heavily featured, catching seven of 11 targets for 98 yards and a score through two games.
Arizona defense is giving up 255.5 passing yards per game, seventh-most in the league, putting added pressure on a secondary facing Christian McCaffrey. He has topped 100 scrimmage yards in each win this season, though he is still searching for his first rush longer than 13 yards.
Arizona has quietly been a strong bet, covering five straight games as an underdog, but San Francisco remains the more complete team on both sides of the ball entering this NFC West matchup.
